Sean Lawler, PhD
Research Assistant Professor of Neurosurgery
The Dardinger Laboratory for Neuro-Oncology and Neurosciences
Curriculum Vitae 
| Office: | (614) 292-3384 |
| Fax: | (614) 688-4882 |
Training
Undergraduate School: B.S., Edinburgh University, UK, 1987 Graduate School: Ph.D., Crystallography, Birkbeck College, University of London, UK, 1992
Postdoctorate Fellowship: Department of Growth and Development, University of California, San Francisco, 1992-1994 Postdoctorate Fellowship: INSERM (National Institute of Health and Medical Research) U153, Paris, France, 1994-1996 Postdoctorate Fellowship: Medical Research Council (MRC), Protein Phosphorylation Unit, University of Dundee, UK, 1996-1998 Postdoctorate Fellowship: Institute of Molecular Medicine, University College London, UK, 1998-1999
Research Interests
Cell signaling in disorders of the central nervous system, including degeneration and cancer.
Dr. Sean Lawler’s laboratory is studying cell signaling mechanisms in disorders of the central nervous system (cancer and neurodegeneration) to ultimately develop novel therapeutic approaches. Using a three-dimensional cell culture system, they are studying the migration and invasion of glioma cells, mechanisms that present a major challenge in brain tumor therapy. They have identified a number of small-molecule drugs that block invasion effectively and are testing these in animal glioma models, and they have identified a number of novel genes that may be important in migration and invasion. In addition, Dr. Lawler’s team is examining the role of the microtubule-associated protein, tau, in neurodegeneration in an effort to explore the potential link between amyloid and tau, which may be critical in the progression of Alzheimer’s disease.
Recent Publications
Lawler SE, Saeki Y, Chiocca EA, Wade-Martins R: iBAC technologies for neurological disease. In: Gene Therapy for Neurological Disorders. (Lowenstein PR, Castro MG, eds.) New York: Taylor & Francis, pp 59-73, 2006.
Lawler SE, Peruzzi PP, Chiocca EA. Genetic strategies for brain tumor therapy. Cancer Gene Therapy. 2006 March; 13(3):225-233. Epublication 2005 September 2. (IF 3.000)
Appointment Year
2004
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of Neurological Surgery, The Ohio State University.