N1021 Doan Hall
410 W. 10th Ave
Columbus, OH 43210
Phone: (614) 293-9312
Fax: (614) 293-4024
Email: ea.chiocca@osumc.edu
Current OSU Appointments
Chair, Neurological Surgery
Physician, NeuroSurgery
Professor, SBS-Neuroscience
Certifications
| 1996 - 2000 | Board-eligible, Neurosurgery: State Medical Board of Ohio |
| 2000 - 2008 | Certified, Neurosurgery, American Board of Neurological Surgery: State Medical Board of Ohio |
Chapters In Books
Davies PJA, Basilion JP, Chiocca EA, Fung WW, Duvic M, Stein JP. 1989. Retinoid regulated gene expression in normal and transformed cells: transcriptional activation of tissue transglutaminase gene expression. In Pharmacology of Retinoids in the Skin. Edited by Reichert U, Schrote B. Basel: Kargel Publishers. 20-28.
Chiocca EA, Martuza RL. 1990. Neurosurgical therapy of the obsessive compulsive disorder. In Obsessive-Compulsive Disorders: Theory and Management, second edition. Edited by Jenike M, Baer L, Minichiello WE. Chicago, Illinois: Year Book Medical Publishers. 283-294.
Chiocca EA, Andersen JK, Takamiya Y, Martuza RL, Breakefield XO. 1994. Virus-mediated genetic treatment of rodent gliomas. In Gene Therapeutics. Edited by Wolff JA. Boston: Birkhauser Press Publishing Co. 245-262.
Breakefield XO, Esteves M, Pechan P, Kramm C, Yoshimoto Y, Lin Q, Davar G, Livermore J, Isacson O, Chiocca EA, Bohn M, Kaye E. 1995. Gene Therapy for the Nervous System--Status 1994. In Genetic Therapy. Bilbao: Fundación BBV.
Breakefield XO, Kramm CM, Chiocca EA, Pechan P. 1995. Herpes simplex virus vectors for tumor therapy. In The Internet Book of Gene Therapy: Cancer Gene Therapeutics. Edited by Sobol R, Scanlon K. City: Prentice Hall Health. 41-56.
Kramm C, Breakefield XO, Chiocca EA. 1995. Genetic strategies against brain tumors. In The Internet Book of Gene Therapy: Cancer Gene Therapeutics. Edited by Sobol R, Scanlon K. city: Prentice Hall Health. 235-246.
Wei MX, Tamiya T, Breakefield XO, Chiocca EA. 1995. Virus vector mediated transfer of drug-sensitivity genes for experimental brain tumor therapy. In Viral Vectors: Gene Therapy and Neuroscience Applications. Edited by Kaplitt MG, Loewy AD. San Diego, California: Academic Press. 239-259.
Chiocca EA. 1997. Experimental and clinical gene therapies for brain tumors. In Gene Therapy for Neurological Disorders and Brain Tumors. Edited by Chiocca EA, Breakefield XO. Totowa, New Jersey: Humana Press, Inc. 191-204.
Chiocca EA, Harsh IV GR. 1997. Gene transfer technology and its application to brain tumor therapy. In The Molecular Basis of Neurosurgical Disease, Volume 8: Concepts in Neurosurgery. Edited by C., Harsh IV G.R. city: Lippincott Williams & Wilkins. 238-247.
Tang G, Chiocca EA. 1997. Gene transfer and delivery for central nervous system disease. In Neurosurgical Focus 3: article 2. city: publisher.
Deisboeck T, Harsh GR, Chiocca EA. 1998. The use of genes for the treatment of cancer. In McGraw-Hill 1999 Yearbook of Science and Technology. Texas: McGraw-Hill.
Chiocca EA, Waxman DJ. 2003. Cytochrome P450-Based Gene Therapies for Cancer. In Suicide Gene Therapy: Methods and Reviews. Edited by Springer C. Totawa, New Jersey: Humana Press, Inc. 203-222.
Saeki Y, Breakefield XO, Chiocca EA. 2003. Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA. In Viral vectors for gene therapy: Methods and Protocols. Edited by Machida CA. Totowa, New Jersey: Humana Press, Inc. 51-60.
Aghi M, Chiocca EA. 2005. Gene-based and viral-based therapies. In Minimally invasive neurosurgery. Edited by Proctor MR, Black PM. Totawa, New Jersey: Humana Press, Inc. 269-296.
Cahill DP, Chiocca EA. 2005. Applications of principles of cellular and molecular biology in neurosurgical disorders. In Principles of neurosurgery. Second edition. Edited by Rengachary SS, Ellenbogen RG. Edinburgh, Scotland: Elsevier Limited. 57-64.
Lamfers MLM, Visted T, Chiocca EA. 2005. Oncolytic viral therapy for glioma. In Principles of molecular neurosurgery. Edited by Freese A, Simeone FA, Leone P, Janson C. Basel, Switzerland: S. Karger AG. 557-579.
Abbed KM, Chiocca EA. 2006. Surgical management of cerebellar astrocytomas in adults. In Operative neurosurgical techniques: Indications, methods, and results. Volume I. Fifth edition. Edited by Schmidek HH, Roberts DW. Philadelphia, Pennsylvania: Saunders Elsevier. 873-880.
Asadi-Moghaddam K, Chiocca EA. 2006. Chemotherapy-activating gene therapy. In Handbook ofbrain tumor therapy. Edited by Newton HB. Philadelphia, Pennsylvania: Academic Press (Elsevier). 332-343.
Asadi-Moghaddam K, Chiocca EA. 2006. Prodrug-activation gene therapy. In Gene therapy in the central nervous system. Edited by Kaplitt MG, During MJ. Philadelphia, Pennsylvania: Academic Press (Elsevier). 291-301.
Lawler SE, Saeki Y, Chiocca EA, Wade-Martins R. 2006. iBAC technologies for neurological disease. In Gene therapy for neurological disorders. Edited by Lowenstein PR, Castro MG. New York: Taylor & Francis. 59-73.
Chiocca EA, Lamfers ML. 2007. Clinical Trials of Oncolytic Viruses for Gliomas. In High-Grade Gliomas: Diagnosis and Treatment. Edited by Barnett GH. Totawa, New Jersey: Humana Press, Inc. 391-404.
Fisher JL, Schwartzbaum JA, Wrensch M, Chiocca EA. 2007. Central nervous system tumors. In Handbook of Clinical Neuroepidemiology. Edited by Feigin VL, Bennett DA. Hauppauge, New York: Nova Science Publishers. 391-421.
Lawler S, Chiocca EA. 2008. Genomic Medicine, Brain Tumors and Gliomas. In Genomic and Personalized Medicine, 2-vol set by Willard. city: publisher. 956-966.
Lawler SE, Chiocca EA. Brain tumors. In The Handbook of Genomic Medicine. Edited by Ginsburg GS, Willard HF. Amsterdam, The Netherlands: Elsevier. (In press)
Continuing Education, Extension, or Other Courses Taught
Grand Rounds
1994 Neurology Grand Rounds. Harvard Medical School (Boston, MA) 100.
1995 Neurosurgical Grand Rounds. Harvard Medical School (Boston, MA) 50.
1996 Neurosurgical Grand Rounds. Harvard Medical School (Boston, MA) 50.
1996 Combined Neurosciences Grand Rounds. Harvard Medical School (Boston, MA) 30.
1997 Hematology/Oncology Grand Rounds. Harvard Medical School (Boston, MA) 50.
1997 Medical Grand Rounds. Brigham and Women's Hospital (Boston, MA) 30.
1997 Neurosciences/Neurology Grand Rounds. Boston University (Boston, MA) 30.
1997 Neurosurgical Grand Rounds. Harvard Medical School (Boston, MA) 50.
1997 Neurology Grand Rounds. Harvard Medical School (Boston, MA) 100.
1998 Neurosurgery Grand Rounds. Brigham and Women's Hospital (Boston, MA) 30.
2005 Surgery Grand Rounds. The Ohio State University Medical Center (Columbus, OH) 40.
Lecture
12/10/2008 Experimental Treatments for Malignant Gliomas. The Ohio State University College of Veterinary Medicine (Columbus, OH)
Degrees
| 1982 | B.S., University of Texas, El Paso |
| 1988 | M.D., The University of Texas Health Science Center at Houston |
| 1988 | Ph.D., The University of Texas Health Science Center at Houston |
Fellowship, Internship or Residency
| 1988 - 1989 | Internship, General Surgery, The University of Texas Health Science Center at Houston, Houston, TX, United States. |
| 1989 - 1995 | Residency, Neurological Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States. |
Honors
| Elected to American Society for Clinical Investigation (ASCI). |
| American Society for Clinical Investigation, Elected. |
| 1988 | Alumni Association Senior Student Research Award. University Of Texas Medical School, Galveston, TX, United States. |
| 1988 | Walter G. Sterling Outstanding Student Award. University of Texas Health Science Center at San Antonio, San Antonio, TX, United States. |
| 1992 - 1994 | Fellow, James B. Plunkett Fellow. University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Subject: American Brain Tumor Association |
| 1994 | Congress of Neurological Surgeons Resident Award. University of Texas Health Science Center at San Antonio, San Antonio, TX, United States. |
| 1994 | American Academy of Neurological Surgeons Honorable Mention. University of Texas Health Science Center at San Antonio, San Antonio, TX, United States. |
| 2001 | Charles B. Wilson Award. National Brain Tumor Foundation.
Subject: National Brain Tumor Foundation |
| 2002 | New Approaches to Brain Therapy (NABTT) Award. National Brain Tumor Foundation.
Subject: National Brain Tumor Foundation |
| 2005 | Inducted as Member to American Society for Clinical Investigation. |
| 2005 | Elected to editorial board. Journal of Neurosurgery.
Subject: Journal of Neurosurgery |
| 2005 | Best Doctors in Central Ohio. Columbus Monthly Magazine.
Subject: Columbus Monthly Magazine |
| 2005 | Elected to membership American Society for Clinical Investigation. |
| 2005 | America's Best Doctors. |
| 2005 | Elected to membership of American Academy of Neurological Surgeons. |
| 2005 | Fellow, AAAS Fellow. American Association for the Advancement of Science (AAAS), Washington, DC, United States.
Subject: Neurological Surgery |
| 2005 - 2007 | Best Doctors in America. |
| 2006 | Rising Star (Research and Development). Columbus CEO magazine.
Subject: Columbus CEO magazine |
| 2006 | Elected to membership Society of Neurological Surgeons. |
| 2006 | Elected to membership of Society of Neurological Surgeons. |
| 2006 - 2007 | Identified as one of "America's Top Doctors for Cancer" (Castle Connolly). |
| 2007 | Elected to editorial board. Neurosurgery.
Subject: Neurosurgery |
| 2007 | Grass Foundation Award in Neurosurgery. |
| 2007 | Lawrence Mervis, M.D. Resident Teacher of the Year Award. Neurosurgery. The Ohio State University Medical Center, Columbus, OH, United States. |
| 2007 | America's Best Doctors. |
| 2008 | Farber Award in Neuro-oncology (Society for Neuro-oncology and CNS/AANS Section on Tumors). The Ohio State University Medical Center, Columbus, OH, United States. |
| 2008 | Voted Best Doctor in Neurological Surgery. Columbus Monthly. |
Licensure
| 1988 - 2008 | Texas License: State of Texas |
| 1989 - 2008 | Massachusetts License: State of Massachusetts |
| 2004 - 2008 | Ohio License: State Medical Board of Ohio |
Memberships
| 1990 - present | Member. Congress of Neurological Surgeons |
| 1997 | Participant. National Cancer Institute. Caner Therapy Evaluation Program |
| 1998 | Participant. Preuss Foundation Advisory Meeting on Immunotherapy for Brain Tumors |
| 1999 | Member. American Society for Gene Therapy (ASGT) Annual Meeting. Abstract Review Group |
| 1999 | Member. International Herpes Simplex Virus (HSV) Workshop. Abstract Review Group |
| 1999 - present | Member. American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Joint Section on Tumors. Executive Council |
| 1999 - present | Member. Executive Committee of the American Association of Neurological Surgery (AANS)/Congress of Neurological Surgery (CNS) Joint Section on tumors |
| 1999 - present | Member. American Society of Gene Therapy |
| 1999 - present | Member. Society for Neuro-Oncology |
| 2000 | Participant. National Cancer Institute/National Institute of Neurological Disorders and Stroke (NCI/NINDS), Bethesda, Maryland. Progress Review Group on Brain Tumors |
| 2000 | Member. ASGT Annual Meeting. Abstract Review Group |
| 2000 - 2005 | Member. National Gene Vector Laboratories (NGVL). Scientific Review Board |
| 2001 | Chair. AANS/CNS. Program Committee, Tumor Section |
| 2001 | Reviewer. Fourteenth International Conference on Brain Tumor Research and Therapy. Abstract Review Group |
| 2001 | Participant. NINDS Conference on Gene Therapy for the Central Nervous System, Rockville, Maryland |
| 2001 - present | Member. American Brain Tumor Association. Scientific Advisory Council |
| 2001 - 2005 | Ad hoc Member. NCI/NINDS Program Project Reviews (NCI-C and D). NINDS Neurological Sciences and Disorders (NSD)-Subcommittee B Study Section |
| 2001 - present | Member. American Association of Neurosurgery |
| 2001 - present | Member. International Society for Neurovirology |
| 2001 - present | Member. American Society for Microbiology |
| 2001 - present | Member. American Society for Experimental Neurotherapeutics |
| 2002 | Member. 14th International Conference on Brain Tumor Research and Therapy. Abstract Review Group |
| 2002 - 2005 | Member. American Cancer Society (ACS). Molecular Genetics and Oncology Study Section |
| 2002 - present | Member. American Board of Neurological Surgery (ABNS). Extramural Subspecialty Writing Committee |
| 2003 | Member. American Society for Gene Therapy (ASGT). Nominating Committee |
| 2003 | Member. European Society for Gene Therapy. Vector Committee |
| 2003 | Chair. AANS/CNS. Program Committee, Tumor Section |
| 2004 | Reviewer. NCI. Specialized Programs of Research Excellence (SPORE) Grants in Neuro-oncology |
| 2004 | Ad hoc Member. Integrative Molecular Analysis Technologies (IMAT) Study Sections. Developmental Therapeutics (DT), Program Project Grant (P01) cluster |
| 2004 - present | Chair. AANS/CNS. "Bylaws” Subcommittee, Tumor Section |
| 2005 - present | Member. NCI. Parent Committee (Scientific Review Council)/ Subcommittee D (Clinical Studies), Program Projects Grants (reviewing clinical/translational studies) |
| 2005 - present | Member. NIH. Developmental Therapeutics (DT) Study Section |
| 2005 - present | Member. American Society for Clinical Investigation |
| 2006 - present | Member. Society of Neurological Surgeons |
| 2006 - present | Associate Member. Center for Brain and Spinal Cord Repair |
| 2006 - present | Member. AANS. Neurosurgery Research and Education Foundation (NREF) Scientific Advisory Committee (SAC) |
| 2006 - present | Member. Goldhirsh Foundation Brain Tumor Research Awards Program. Scientific Advisory Committee |
| 2006 - present | Member. Society for Neuro-oncology. Education Committee |
| 2006 - present | Member. Society for Neurological Surgeons. Education Committee |
| 2006 - present | Member. Society for Neuro-oncology. Awards Committee |
| 2007 - present | Member. Society of Neurological Surgeons. Research Committee |
| 2007 | Ad hoc Member. National Cancer Institute, Canada |
| 2007 - present | Editor. Youmans Textbook of Neurosurgery, Sixth Edition. Section Editor (Brain Tumors) |
| 2007 - present | Member. Ceregene Corporation, East Elmhurst, New York. Data Monitoring Committee (DMC) |
| 2007 | Ad hoc Member. Alliance for Cancer Gene Therapy |
| 2007 | Reviewer. NCI. Specialized Programs of Research Excellence (SPORE) Grants in Neuro-oncology |
| 2008 | Reviewer. American Society for Gene Therapy Annual Meeting |
| 2009 | Reviewer. NINDS. Board of Scientific Councillors |
Peer Reviewed Journal Articles
Guevara, J Jr; Chiocca, E, A; Clayton, F, C; von Eschenbach, A, C; Edwards, J J. 1982. A simple method of eluting proteins from two-dimensional gels. Clinical chemistry. Vol. 28, no. 4 Pt 2: 756-8.
Chiocca, E, A; Davies, P, J; Stein, J P. 1988. The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages. The Journal of biological chemistry. Vol. 263, no. 23: 11584-9.
Davies, P, J; Basilion, J, P; Chiocca, E, A; Johnson, J; Poddar, S; Stein, J P. 1988. Retinoids as generalized regulators of cellular growth and differentiation. The American journal of the medical sciences. Vol. 296, no. 3: 164-70.
Davies, P, J; Chiocca, E, A; Basilion, J, P; Poddar, S; Stein, J P. 1988. Transglutaminases and their regulation: implications for polyamine metabolism. Advances in experimental medicine and biology. Vol. 250: 391-401.
Davies, P, J; Chiocca, E, A; Stein, J P. 1988. Retinoid--regulated expression of tissue transglutaminase in normal and leukemic myeloid cells. Advances in experimental medicine and biology. Vol. 231: 63-71.
Chiocca, E, A; Davies, P, J; Stein, J P. 1989. Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation. Journal of cellular biochemistry. Vol. 39, no. 3: 293-304.
Chiocca, E, A; Choi, B, B; Cai, W, Z; DeLuca, N, A; Schaffer, P, A; DiFiglia, M; Breakefield, X, O; Martuza, R L. 1990. Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. The New biologist. Vol. 2, no. 8: 739-46.
Citterio F, Chiocca EA, Kahan BD. 1990. Nuclear effects of cyclosporine. Transplantation Proceedings 22: 1742-1743.
Lee, J, K; Choi, B; Sobel, R, A; Chiocca, E, A; Martuza, R L. 1990. Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone. Journal of neurosurgery. Vol. 73, no. 3: 429-35.
Lee, J, K; Kim, T, S; Chiocca, E, A; Medhkour, A; Martuza, R L. 1990. Growth of human schwannomas in the subrenal capsule of the nude mouse. Neurosurgery. Vol. 26, no. 4: 598-605.
Martuza, R, L; Chiocca, E, A; Jenike, M, A; Giriunas, I, E; Ballantine, H T. 1990. Stereotactic radiofrequency thermal cingulotomy for obsessive compulsive disorder. The Journal of neuropsychiatry and clinical neurosciences. Vol. 2, no. 3: 331-6.
Gentile, V; Saydak, M; Chiocca, E, A; Akande, O; Birckbichler, P, J; Lee, K, N; Stein, J, P; Davies, P J. 1991. Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. The Journal of biological chemistry. Vol. 266, no. 1: 478-83.
Lee, J, K; Sobel, R, A; Chiocca, E, A; Kim, T, S; Martuza, R L. 1992. Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. Journal of neuro-oncology. Vol. 14, no. 2: 101-12.
EA, Tamiya T, Boviatsis EJ, Filipek PA, Breakefield XO, Kennedy DN. 1993. [Gene therapy for gliomas using virus vectors]. ]. Neuroimmunology Research 6 (Japan): 23-32 (Japanese; abstract in English).
Yu, J, S; Wei, M, ; XChiocca, E, A; Martuza, R, L; Tepper, R I. 1993. Treatment of glioma by engineered interleukin 4-secreting cells. Cancer research. Vol. 53, no. 13: 3125-8.
Boviatsis, E, J; Chase, M; Wei, M, ; XTamiya, T; Hurford, R K Jr; Kowall, N, W; Tepper, R, I; Breakefield, X, O; Chiocca, E A. 1994. Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. Human gene therapy. Vol. 5, no. 2: 183-91.
Boviatsis, E, J; Park, J, S; Sena-Esteves, M; Kramm, C, M; Chase, M; Efird, J, T; Wei, M, ; XBreakefield, X, O; Chiocca, E A. 1994. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer research. Vol. 54, no. 22: 5745-51.
Boviatsis, E, J; Scharf, J, M; Chase, M; Harrington, K; Kowall, N, W; Breakefield, X, O; Chiocca, E A. 1994. Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene therapy. Vol. 1, no. 5: 323-31.
Chiocca, E, A; Boviatsis, E, J; Westmark, R, M; Short, M, P; Richardson, E, P; Zervas, N T. 1994. Deep sylvian fissure meningioma without dural attachment in an adult: case report. Neurosurgery. Vol. 35, no. 5: 944-6; discussion 946.
Pakzaban, P; Chiocca, E A. 1994. Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum. Neuroreport. Vol. 5, no. 8: 993-6.
Scharf JM, Boviatsis EJ, Fleet C, Breakefield XO, Chiocca EA. 1994. Genetically modified rat 9L gliosarcoma cells facilitate detection of infiltrating tumor cells in a rat model of brain neoplasms. Transgenics 1: 219-224.
Tamiya, T; Ohmoto, T; Wei, M, ; XBreakfield, X, O; Chiocca, E A. 1994. [Gene therapy for brain tumors: gene therapy for malignant brain tumors using prodrug-sensitivity genes (series 4)]. No shinkei geka. Neurological surgery. Vol. 22, no. 12: 1099-110.
Wei, M, ; XTamiya, T; Chase, M; Boviatsis, E, J; Chang, T, K; Kowall, N, W; Hochberg, F, H; Waxman, D, J; Breakefield, X, O; Chiocca, E A. 1994. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Human gene therapy. Vol. 5, no. 8: 969-78.
Chiocca, E A. 1995. Brain tumor gene therapy in mice with a novel "suicide" gene: the cyclophosphamide-activating CYP2B1 gene. Clinical neurosurgery. Vol. 42: 370-82.
Kramm, C, M; Sena-Esteves, M; Barnett, F, H; Rainov, N, G; Schuback, D, E; Yu, J, S; Pechan, P, A; Paulus, W; Chiocca, E, A; Breakefield, X O. 1995. Gene therapy for brain tumors. Brain Pathol. Vol. 5, no. 4: 345-81.
Muldoon, L, L; Nilaver, G; Kroll, R, A; Pagel, M, A; Breakefield, X, O; Chiocca, E, A; Davidson, B, L; Weissleder, R; Neuwelt, E A. 1995. Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. American journal of pathology. Vol. 147, no. 6: 1840-51.
Rainov, N, G; Zimmer, C; Chase, M; Kramm, C, M; Chiocca, E, A; Weissleder, R; Breakefield, X O. 1995. Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms. Human gene therapy. Vol. 6, no. 12: 1543-52.
Speliotes EK, Wei MX, Weise J, Fleet C, Do T, Shanti B, Chiocca EA, Finklestein SP, Breakefield XO. 1995. Basic fibroblast growth factor bearing a signal peptide transforms fibroblasts in culture but restricts fibroma growth in brain. Transgenics 1: 573-584.
Tamiya, T; Wei, M, ; XChase, M; Ono, Y; Lee, F; Breakefield, X, O; Chiocca, E A. 1995. Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells. Gene therapy. Vol. 2, no. 8: 531-8.
Wei, M, ; XTamiya, T; Hurford, R K Jr; Boviatsis, E, J; Tepper, R, I; Chiocca, E A. 1995. Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer. Human gene therapy. Vol. 6, no. 4: 437-43.
Wei, M, ; XTamiya, T; Rhee, R, J; Breakefield, X, O; Chiocca, E A. 1995. Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm. Clinical cancer research : an official journal of the American Association for Cancer Research. Vol. 1, no. 10: 1171-7.
Carroll, N, M; Chiocca, E, A; Takahashi, K; Tanabe, K K. 1996. Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus. Annals of surgery. Vol. 224, no. 3: 323-9; discussion 329.
Kramm, C, M; Rainov, N, G; Sena-Esteves, M; Barnett, F, H; Chase, M; Herrlinger, U; Pechan, P, A; Chiocca, E, A; Breakefield, X O. 1996. Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Human gene therapy. Vol. 7, no. 16: 1989-94.
Kramm, C, M; Rainov, N, G; Sena-Esteves, M; Chase, M; Pechan, P, A; Chiocca, E, A; Breakefield, X O. 1996. Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors. Human gene therapy. Vol. 7, no. 3: 291-300.
Megerian, C, A; Chiocca, E, A; McKenna, M, J; Harsh, G F 4th; Ojemann, R G. 1996. The subtemporal-transpetrous approach for excision of petroclival tumors. The American journal of otology. Vol. 17, no. 5: 773-9.
Pechan, P, A; Fotaki, M; Thompson, R, L; Dunn, R; Chase, M; Chiocca, E, A; Breakefield, X O. 1996. A novel 'piggyback' packaging system for herpes simplex virus amplicon vectors. Human gene therapy. Vol. 7, no. 16: 2003-13.
Rainov NG, Kramm CM, Aboody-Guterman K, Chase M, Ueki K, Louis DN, Harsh IV GR, Chiocca EA, Breakefield XO. 1996. Retrovirus-mediated gene therapy of experimental brain neoplasms using the herpes simplex virus–thymidine kinase/ganciclovir paradigm. Cancer Gene Therapy 3: 99-106.
Tamiya, T; Ono, Y; Wei, M, ; XMroz, P, J; Moolten, F, L; Chiocca, E A. 1996. Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer gene therapy. Vol. 3, no. 3: 155-62.
Carroll, N, M; Chase, M; Chiocca, E, A; Tanabe, K K. 1997. The effect of ganciclovir on herpes simplex virus-mediated oncolysis. The Journal of surgical research. Vol. 69, no. 2: 413-7.
Kramm, C, M; Chase, M; Herrlinger, U; Jacobs, A; Pechan, P, A; Rainov, N, G; Sena-Esteves, M; Aghi, M; Barnett, F, H; Chiocca, E, A; Breakefield, X O. 1997. Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy. Human gene therapy. Vol. 8, no. 17: 2057-68.
Ono, Y; Ikeda, K; Wei, M, ; XHarsh, G R 4th; Tamiya, T; Chiocca, E A. 1997. Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Human gene therapy. Vol. 8, no. 17: 2043-55.
Tang G, Chiocca EA. 1997. Gene transfer and delivery in central nervous system disease. Neurosurgical Focus 3: Article 2. (September 15).
Aghi, M; Kramm, C, M; Chou, T, C; Breakefield, X, O; Chiocca, E A. 1998. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. Journal of the National Cancer Institute. Vol. 90, no. 5: 370-80.
Chase, M; Chung, R, Y; Chiocca, E A. 1998. An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy. Nature biotechnology. Vol. 16, no. 5: 444-8.
Chung, R, Y; Chiocca, E A. 1998. Gene therapy for tumors of the central nervous system. Surgical oncology clinics of North America. Vol. 7, no. 3: 589-602.
Herrlinger, U; Kramm, C, M; Aboody-Guterman, K, S; Silver, J, S; Ikeda, K; Johnston, K, M; Pechan, P, A; Barth, R, F; Finkelstein, D; Chiocca, E, A; Louis, D, N; Breakefield, X O. 1998. Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector. Gene therapy. Vol. 5, no. 6: 809-19.
Husain, N; Chiocca, E, A; Rainov, N; Louis, D, N; Zervas, N T. 1998. Co-expression of Fas and Fas ligand in malignant glial tumors and cell lines. Acta neuropathologica. Vol. 95, no. 3: 287-90.
Moore, A; Basilion, J, P; Chiocca, E, A; Weissleder, R. 1998. Measuring transferrin receptor gene expression by NMR imaging. Biochimica et biophysica acta. Vol. 1402, no. 3: 239-49.
Nicolo, M; Chiocca, E A. 1998. Marker gene transfer and oncolysis of human Y79 retinoblastoma cells mediated by herpes simplex virus mutants. Ophthalmic research. Vol. 30, no. 1: 30-6.
Rainov, N, G; Dobberstein, K, U; Heidecke, V; Dorant, U; Chase, M; Kramm, C, M; Chiocca, E, A; Breakefield, X O. 1998. Long-term survival in a rodent brain tumor model by bradykinin-enhanced intra-arterial delivery of a therapeutic herpes simplex virus vector. Cancer gene therapy. Vol. 5, no. 3: 158-62.
Rainov, N, G; Dobberstein, K, U; Sena-Esteves, M; Herrlinger, U; Kramm, C, M; Philpot, R, M; Hilton, J; Chiocca, E, A; Breakefield, X O. 1998. New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Human gene therapy. Vol. 9, no. 9: 1261-73.
Rainov, N, G; Sena-Esteves, M; Fraefel, C; Dobberstein, K, U; Chiocca, E, A; Breakefield, X O. 1998. A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma. Advances in experimental medicine and biology. Vol. 451: 393-403.
Saeki, Y; Ichikawa, T; Saeki, A; Chiocca, E, A; Tobler, K; Ackermann, M; Breakefield, X, O; Fraefel, C. 1998. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Human gene therapy. Vol. 9, no. 18: 2787-94.
Shafqat, S; Elkind, M, S; Chiocca, E, A; Takeoka, M; Koroshetz, W J. 1998. Petroclival meningioma presenting with pathological laughter. Neurology. Vol. 50, no. 6: 1918-9.
Wei, M, ; XLi, F; Ono, Y; Gauldie, J; Chiocca, E A. 1998. Effects on brain tumor cell proliferation by an adenovirus vector that bears the interleukin-4 gene. Journal of neurovirology. Vol. 4, no. 2: 237-41.
Yoon, S, S; Carroll, N, M; Chiocca, E, A; Tanabe, K K. 1998. Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector. Annals of surgery. Vol. 228, no. 3: 366-74.
Aghi, M; Chou, T, C; Suling, K; Breakefield, X, O; Chiocca, E A. 1999. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer research. Vol. 59, no. 16: 3861-5.
Barnett, F, H; Rainov, N, G; Ikeda, K; Schuback, D, E; Elliott, P; Kramm, C, M; Chase, M; Qureshi, N, H; Harsh, G 4th; Chiocca, E, A; Breakefield, X O. 1999. Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7. Cancer gene therapy. Vol. 6, no. 1: 14-20.
Carter, B, S; Zervas, N, T; Chiocca, E A. 1999. Neurogenetic surgery: current limitations and the promise of gene- and virus-based therapies. Clinical neurosurgery. Vol. 45: 226-46.
Chung, R, Y; Saeki, Y; Chiocca, E A. 1999. B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells. Journal of virology. Vol. 73, no. 9: 7556-64.
Ikeda, K; Ichikawa, T; Wakimoto, H; Silver, J, S; Deisboeck, T, S; Finkelstein, D; Harsh, G R 4th; Louis, D, N; Bartus, R, T; Hochberg, F, H; Chiocca, E A. 1999. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nature medicine. Vol. 5, no. 8: 881-7.
Ikeda, K; Saeki, Y; Gonzalez-Agosti, C; Ramesh, V; Chiocca, E A. 1999. Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer. Journal of neurosurgery. Vol. 91, no. 1: 85-92.
Neuwelt, E, A; Abbott, N, J; Drewes, L; Smith, Q, R; Couraud, P, O; Chiocca, E, A; Audus, K, L; Greig, N, H; Doolittle, N D. 1999. Cerebrovascular Biology and the various neural barriers: challenges and future directions. Neurosurgery. Vol. 44, no. 3: 604-8; discussion 608.
Qureshi, N, H; Chiocca, E A. 1999. A review of gene therapy for the treatment of central nervous system tumors. Critical reviews in oncogenesis. Vol. 10, no. 4: 261-74.
Rainov, N, G; Ikeda, K; Qureshi, N, H; Grover, S; Herrlinger, U; Pechan, P; Chiocca, E, A; Breakefield, X, O; Barnett, F H. 1999. Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms. Human gene therapy. Vol. 10, no. 2: 311-8.
Rainov, N, G; Ikeda, K; Qureshi, N; Grover, S; Barnett, F, H; Herrlinger, U; Quinones, A; Chiocca, E, A; Breakefield, X O. 1999. Intra-arterial virus and nonvirus vector-mediated gene transfer to experimental rat brain tumors. Frontiers of radiation therapy and oncology. Vol. 33: 227-40.
Sena-Esteves, M; Saeki, Y; Camp, S, M; Chiocca, E, A; Breakefield, X O. 1999. Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons. Journal of virology. Vol. 73, no. 12: 10426-39.
Yoon, S, S; Carroll, N, M; Chiocca, E, A; Tanabe, K K. 1999. Influence of p53 on herpes simplex virus type 1 vectors for cancer gene therapy. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. Vol. 3, no. 1: 34-48.
Basilion JP, Ichikawa T, Chiocca EA. 2000. Gene therapy of brain tumors: problems presented by physiological barriers. Neurosurgical Focus. Vol. 8, no. 4.
Harsh, G, R; Deisboeck, T, S; Louis, D, N; Hilton, J; Colvin, M; Silver, J, S; Qureshi, N, H; Kracher, J; Finkelstein, D; Chiocca, E, A; Hochberg, F H. 2000. Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study. Journal of neurosurgery. Vol. 92, no. 5: 804-11.
Ichikawa, T; Saeki, Y; Tamiya, T; Chiocca, E, A; Ohmoto, T. 2000. [Herpes simplex type-1 virus-based vectors for gene therapy]. Nippon rinsho. Japanese journal of clinical medicine. Vol. 58, no. 4: 822-7.
Ikeda, K; Wakimoto, H; Ichikawa, T; Jhung, S; Hochberg, F, H; Louis, D, N; Chiocca, E A. 2000. Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant. Journal of virology. Vol. 74, no. 10: 4765-75.
Kansal, A, R; Torquato, S; Chiocca, E, A; Deisboeck, T S. 2000. Emergence of a subpopulation in a computational model of tumor growth. Journal of theoretical biology. Vol. 207, no. 3: 431-41.
Kansal, A, R; Torquato, S; Harsh GR, I, V; Chiocca, E, A; Deisboeck, T S. 2000. Simulated brain tumor growth dynamics using a three-dimensional cellular automaton. Journal of theoretical biology. Vol. 203, no. 4: 367-82.
Kansal, A, R; Torquato, S; Harsh IV, G, R; Chiocca, E, A; Deisboeck, T S. 2000. Cellular automaton of idealized brain tumor growth dynamics. Bio Systems. Vol. 55, no. 1-3: 119-27.
Lim, D, J; Rubenstein, A, E; Evans, D, G; Jacks, T; Seizinger, B, G; Baser, M, E; Beebe, D; Brackmann, D, E; Chiocca, E, A; Fehon, R, G; Giovannini, M; Glazer, R; Gusella, J, F; Gutmann, D, H; Korf, B; Lieberman, F; Martuza, R; McClatchey, A, I; Parry, D, M; Pulst, S, M; et al. 2000. Advances in neurofibromatosis 2 (NF2): a workshop report. Journal of neurogenetics. Vol. 14, no. 2: 63-106.
Misdraji, J; Ino, Y; Louis, D, N; Rosenberg, A, E; Chiocca, E, A; Harris, N L. 2000. Primary lymphoma of peripheral nerve: report of four cases. The American journal of surgical pathology. Vol. 24, no. 9: 1257-65.
Pawlik, T, M; Nakamura, H; Yoon, S, S; Mullen, J, T; Chandrasekhar, S; Chiocca, E, A; Tanabe, K K. 2000. Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus. Cancer research. Vol. 60, no. 11: 2790-5.
Quinones-Hinojosa, A; Friedlander, R, M; Boyer, P, J; Batchelor, T, T; Chiocca, E A. 2000. Solitary sciatic nerve lymphoma as an initial manifestation of diffuse neurolymphomatosis. Case report and review of the literature. Journal of neurosurgery. Vol. 92, no. 1: 165-9.
Qureshi, N, H; Bankiewicz, K, S; Louis, D, N; Hochberg, F, H; Chiocca, E, A; Harsh, G R 4th. 2000. Multicolumn infusion of gene therapy cells into human brain tumors: technical report. Neurosurgery. Vol. 46, no. 3: 663-8; discussion 668.
Smith, E, R; Chiocca, E A. 2000. Oncolytic viruses as novel anticancer agents: turning one scourge against another. Expert opinion on investigational drugs. Vol. 9, no. 2: 311-27.
Spear, M, A; Sun, F; Eling, D, J; Gilpin, E; Kipps, T, J; Chiocca, E, A; Bouvet, M. 2000. Cytotoxicity, apoptosis, and viral replication in tumor cells treated with oncolytic ribonucleotide reductase-defective herpes simplex type 1 virus (hrR3) combined with ionizing radiation. Cancer gene therapy. Vol. 7, no. 7: 1051-9.
Weissleder, R; Moore, A; Mahmood, U; Bhorade, R; Benveniste, H; Chiocca, E, A; Basilion, J P. 2000. In vivo magnetic resonance imaging of transgene expression. Nature medicine. Vol. 6, no. 3: 351-5.
Yoon, S, S; Nakamura, H; Carroll, N, M; Bode, B, P; Chiocca, E, A; Tanabe, K K. 2000. An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Vol. 14, no. 2: 301-11.
Deisboeck, T, S; Berens, M, E; Kansal, A, R; Torquato, S; Stemmer-Rachamimov, A, O; Chiocca, E A. 2001. Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model. Cell proliferation. Vol. 34, no. 2: 115-34.
Ichikawa, T; Chiocca, E A. 2001. Comparative analyses of transgene delivery and expression in tumors inoculated with a replication-conditional or -defective viral vector. Cancer research. Vol. 61, no. 14: 5336-9.
Ichikawa, T; Petros, W, P; Ludeman, S, M; Fangmeier, J; Hochberg, F, H; Colvin, O, M; Chiocca, E A. 2001. Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector. Cancer research. Vol. 61, no. 3: 864-8.
Jacobs, A; Tjuvajev, J, G; Dubrovin, M; Akhurst, T; Balatoni, J; Beattie, B; Joshi, R; Finn, R; Larson, S, M; Herrlinger, U; Pechan, P, A; Chiocca, E, A; Breakefield, X, O; Blasberg, R G. 2001. Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer research. Vol. 61, no. 7: 2983-95.
Nuñez R, Ackermann M, Saeki Y, Chiocca EA, Fraefel C. 2001. Flow cytometric assessment of transduction efficiency and cytotoxicity of herpes simplex virus type 1-based amplicon vectors. Cytometry 44: 93-99.
Saeki, Y; Fraefel, C; Ichikawa, T; Breakefield, X, O; Chiocca, E A. 2001. Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 3, no. 4: 591-601.
Wade-Martins, R; Smith, E, R; Tyminski, E; Chiocca, E, A; Saeki, Y. 2001. An infectious transfer and expression system for genomic DNA loci in human and mouse cells. Nature biotechnology. Vol. 19, no. 11: 1067-70.
Abe, Tatsuya; Wakimoto, Hiroaki; Bookstein, Robert; Maneval, Daniel, C; Chiocca, E Antonio; Basilion, James P. 2002. Intra-arterial delivery of p53-containing adenoviral vector into experimental brain tumors. Cancer gene therapy. Vol. 9, no. 3: 228-35.
Chiocca, E Antonio. 2002. Guided genes for tumor warfare. Nature biotechnology. Vol. 20, no. 3: 235-6.
Chiocca, E Antonio. 2002. Oncolytic viruses. Nature reviews. Cancer. Vol. 2, no. 12: 938-50.
Ichikawa, Tomotsugu; Hogemann, Dagmar; Saeki, Yoshinaga; Tyminski, Edyta; Terada, Kinya; Weissleder, Ralph; Chiocca, E Antonio; Basilion, James P. 2002. MRI of transgene expression: correlation to therapeutic gene expression. Neoplasia. Vol. 4, no. 6: 523-30.
Nakamura, Hideo; Kasuya, Hideki; Mullen, John, T; Yoon, Sam, S; Pawlik, Timothy, M; Chandrasekhar, Soundararajalu; Donahue, James, M; Chiocca, E Antonio; Chung, Richard, Y; Tanabe, Kenneth K. 2002. Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5. The Journal of clinical investigation. Vol. 109, no. 7: 871-82.
Pawlik, Timothy, M; Nakamura, Hideo; Mullen, John, T; Kasuya, Hideki; Yoon, Sam, S; Chandrasekhar, Soundararajalu; Chiocca, E Antonio; Tanabe, Kenneth K. 2002. Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene. Cancer. Vol. 95, no. 5: 1171-81.
Rabinov, James, D; Lee, Patricia Lani; Barker, Frederick, G; Louis, David, N; Harsh, Griffith, R; Cosgrove, G Rees; Chiocca, E Antonio; Thornton, Allan, F; Loeffler, Jay, S; Henson, John, W; Gonzalez, R Gilberto. 2002. In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology. Vol. 225, no. 3: 871-9.
Smith, Edward, R; Ott, Mark; Wain, John; Louis, David, N; Chiocca, E Antonio. 2002. Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature. Journal of neurosurgery. Vol. 96, no. 1 Suppl: 107-11.
Wakimoto, Hiroaki; Ikeda, Keiro; Abe, Tatsuya; Ichikawa, Tomotsugu; Hochberg, Fred, H; Ezekowitz, R Alan, B; Pasternack, Mark, S; Chiocca, E Antonio. 2002. The complement response against an oncolytic virus is species-specific in its activation pathways. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 5, no. 3: 275-82.
Abe, Tatsuya; Terada, Kinya; Wakimoto, Hiroaki; Inoue, Ryo; Tyminski, Edyta; Bookstein, Robert; Basilion, James, P; Chiocca, E Antonio. 2003. PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Cancer research. Vol. 63, no. 9: 2300-5.
Aghi, Manish; Chiocca, E A. 2003. Genetically engineered herpes simplex viral vectors in the treatment of brain tumors: a review. Cancer investigation. Vol. 21, no. 2: 278-92.
Chiocca, E Antonio. 2003. Gene therapy: a primer for neurosurgeons. Neurosurgery. Vol. 53, no. 2: 364-73; discussion 373.
Chiocca, E Antonio; Aghi, Manish; Fulci, Giulia. 2003. Viral therapy for glioblastoma. Cancer J. Vol. 9, no. 3: 167-79.
Deisboeck, T, S; Wakimoto, H; Nestler, U; Louis, D, N; Sehgal, P, K; Simon, M; Chiocca, E, A; Hochberg, F H. 2003. Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study. Gene therapy. Vol. 10, no. 15: 1225-33.
Hampl, Jurgen, A; Camp, Sara, M; Mydlarz, Wojciech, K; Hampl, Monika; Ichikawa, Tomotsuga; Chiocca, E Antonio; Louis, David, N; Sena-Esteves, Miguel; Breakefield, Xandra O. 2003. Potentiated gene delivery to tumors using herpes simplex virus/Epstein-Barr virus/RV tribrid amplicon vectors. Human gene therapy. Vol. 14, no. 7: 611-26.
Kubo, Shuji; Saeki, Yoshinaga; Chiocca, E Antonio; Mitani, Kohnosuke. 2003. An HSV amplicon-based helper system for helper-dependent adenoviral vectors. Biochemical and biophysical research communications. Vol. 307, no. 4: 826-30.
Packard, Scott, D; Mandeville, Joseph, B; Ichikawa, Tomotsugu; Ikeda, Keiro; Terada, Kinya; Niloff, Stephanie; Chiocca, E Antonio; Rosen, Bruce, R; Marota, John J A. 2003. Functional response of tumor vasculature to PaCO2: determination of total and microvascular blood volume by MRI. Neoplasia. Vol. 5, no. 4: 330-8.
Saeki, Yoshinaga; Breakefield, Xandra, O; Chiocca, E Antonio. 2003. Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA. Methods in molecular medicine. Vol. 76: 51-60.
Wade-Martins, Richard; Saeki, Yoshinaga; Chiocca, E Antonio. 2003. Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 7, no. 5 Pt 1: 604-12.
Wakimoto, H; Johnson, P, R; Knipe, D, M; Chiocca, E A. 2003. Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene therapy. Vol. 10, no. 11: 983-90.
Fulci G, Chiocca EA. 2003. Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review. Frontiers in Bioscience 8. (May 1): E346-360.
Chiocca, E Antonio; Abbed, Khalid, M; Tatter, Stephen; Louis, David, N; Hochberg, Fred, H; Barker, Fred; Kracher, Jean; Grossman, Stuart, A; Fisher, Joy, D; Carson, Kathryn; Rosenblum, Mark; Mikkelsen, Tom; Olson, Jeff; Markert, James; Rosenfeld, Steven; Nabors, L Burt; Brem, Steven; Phuphanich, Surasak; Freeman, Scott; Kaplan, Rick; et al. 2004. A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 10, no. 5: 958-66.
Chiocca, E Antonio; Broaddus, William, C; Gillies, George, T; Visted, Therese; Lamfers, Martine L M. 2004. Neurosurgical delivery of chemotherapeutics, targeted toxins, genetic and viral therapies in neuro-oncology. Journal of neuro-oncology. Vol. 69, no. 1-3: 101-17.
Chiocca, E Antonio; Waxman, David J. 2004. Cytochrome p450-based gene therapies for cancer. Methods in molecular medicine. Vol. 90: 203-22.
Ichikawa, Tomotsugu; Terada, Kinya; Tamiya, Takashi; Basilion, James, P; Chiocca, E Antonio; Date, Isao. 2004. [Molecular imaging of transgene expression in brain tumors]. No shinkei geka. Neurological surgery. Vol. 32, no. 8: 805-24.
Inoue, R; Moghaddam, K, A; Ranasinghe, M; Saeki, Y; Chiocca, E, A; Wade-Martins, R. 2004. Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells. Gene therapy. Vol. 11, no. 15: 1195-204.
Lev, Michael, H; Ozsunar, Yelda; Henson, John, W; Rasheed, Amjad, A; Barest, Glenn, D; Harsh, Griffith R 4th; Fitzek, Markus, M; Chiocca, E Antonio; Rabinov, James, D; Csavoy, Andrew, N; Rosen, Bruce, R; Hochberg, Fred, H; Schaefer, Pamela, W; Gonzalez, R Gilberto. 2004. Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR. American journal of neuroradiology. Vol. 25, no. 2: 214-21.
Nestler, Ulf; Wakimoto, Hiroaki; Siller-Lopez, Fernando; Aguilar, Laura, K; Chakravarti, Arnab; Muzikansky, Alona; Stemmer-Rachamimov, Anat; Chiocca, E Antonio; Aguilar-Cordova, Estuardo; Hochberg, Fred H. 2004. The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects. Journal of neuro-oncology. Vol. 67, no. 1-2: 177-88.
Post, Dawn, E; Fulci, Giulia; Chiocca, E Antonio; Van Meir, Erwin G. 2004. Replicative oncolytic herpes simplex viruses in combination cancer therapies. Current gene therapy. Vol. 4, no. 1: 41-51.
Wakimoto, H; Fulci, G; Tyminski, E; Chiocca, E Antonio. 2004. Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene therapy. Vol. 11, no. 2: 214-23.
Aghi, Manish; Chiocca, E Antonio. 2005. Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 12, no. 6: 994-1005.
Brem SS, Bierman PJ, Black P, Blumenthal DT, Brem H, Chamberlain MC, Chiocca EA, DeAngelis LM, Fernstermaker RA, Fine HA, Friedman A, Glass J, Grossman SA, Heimberger AB, Junck L, Levin V, Loeffler JJ, Maor MH, Narayana A, Newton HB, Olivi A, Portnow J,. 2005. National Comprehensive Cancer Network. Central nervous system cancers: clinical practice guidelines in oncology. Journal of the National Comprehensive Cancer Network 3: 644-690.
Kambara, Hirokazu; Okano, Hideyuki; Chiocca, E Antonio; Saeki, Yoshinaga. 2005. An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer research. Vol. 65, no. 7: 2832-9.
Kambara, Hirokazu; Saeki, Yoshinaga; Chiocca, E Antonio. 2005. Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus. Cancer research. Vol. 65, no. 24: 11255-8.
Lamfers, Martine L, M; Gianni, Davide; Tung, Ching-Hsuan; Idema, Sander; Schagen, Frederik H, E; Carette, Jan, E; Quax, Paul H, A; Van Beusechem, Victor, W; Vandertop, W Peter; Dirven, Clemens M, F; Chiocca, E Antonio; Gerritsen, Winald R. 2005. Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Cancer research. Vol. 65, no. 20: 9398-405.
MacCollin, M; Chiocca, E, A; Evans, D, G; Friedman, J, M; Horvitz, R; Jaramillo, D; Lev, M; Mautner, V, F; Niimura, M; Plotkin, S, R; Sang, C, N; Stemmer-Rachamimov, A; Roach, E S. 2005. Diagnostic criteria for schwannomatosis. Neurology. Vol. 64, no. 11: 1838-45.
Tyminski, Edyta; Leroy, Stanley; Terada, Kinya; Finkelstein, Dianne, M; Hyatt, Janice, L; Danks, Mary, K; Potter, Philip, M; Saeki, Yoshinaga; Chiocca, E Antonio. 2005. Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan. Cancer research. Vol. 65, no. 15: 6850-7.
Aghi, Manish; Chiocca, E Antonio. 2006. Gene therapy for glioblastoma. Neurosurgical focus [electronic resource]. Vol. 20, no. 4: E18.
Aghi, Manish; Cohen, Kenneth, S; Klein, Rachael, J; Scadden, David, T; Chiocca, E Antonio. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer research. Vol. 66, no. 18.
Cutter, Jennifer, L; Kurozumi, Kazuhiko; Chiocca, E Antonio; Kaur, Balveen. 2006. Gene therapeutics: the future of brain tumor therapy?. Expert review of anticancer therapy. Vol. 6, no. 7: 1053-64.
Friedman, Avner; Tian, Jianjun Paul; Fulci, Giulia; Chiocca, E Antonio; Wang, Jin. 2006. Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity. Cancer research. Vol. 66, no. 4: 2314-9.
Fulci, Giulia; Breymann, Laura; Gianni, Davide; Kurozomi, Kazuhiko; Rhee, Sarah, S; Yu, Jianhua; Kaur, Balveen; Louis, David, N; Weissleder, Ralph; Caligiuri, Michael, A; Chiocca, E Antonio. 2006. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 34: 12873-8.
Kaur, Balveen; Chiocca, E Antonio. 2006. Oncolytic viruses: extreme treatment for an extreme disease. Future microbiology. Vol. 1.
Lamfers, Martine L, M; Fulci, Giulia; Gianni, Davide; Tang, Yi; Kurozumi, Kazuhiko; Kaur, Balveen; Moeniralm, Sharif; Saeki, Yoshinaga; Carette, Jan, E; Weissleder, Ralph; Vandertop, W Peter; van Beusechem, Victor, W; Dirven, Clemens M, F; Chiocca, E Antonio. 2006. Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 14, no. 6.
Lawler, S, E; Peruzzi, P, P; Chiocca, E A. 2006. Genetic strategies for brain tumor therapy. Cancer gene therapy. Vol. 13, no. 3: 225-33.
Sarkar, Atom; Chiocca, E Antonio. 2006. Prognostic indicators. Journal of neurosurgery. Vol. 105, no. 2.
Terada, K; Wakimoto, H; Tyminski, E; Chiocca, E, A; Saeki, Y. 2006. Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models. Gene therapy. Vol. 13, no. 8: 705-14.
Thoman, W James; Ammirati, Mario; Caragine, Louis P Jr; McGregor, John, M; Sarkar, Atom; Chiocca, E Antonio. 2006. Brain tumor imaging and surgical management: the neurosurgeon's perspective. Topics in magnetic resonance imaging : TMRI. Vol. 17, no. 2.
Yamamoto, S; Deckter, L, A; Kasai, K; Chiocca, E, A; Saeki, Y. 2006. Imaging immediate-early and strict-late promoter activity during oncolytic herpes simplex virus type 1 infection and replication in tumors. Gene therapy. Vol. 13, no. 24.
Aiuti A, Bachoud-Lévi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA, Leen AM Lemoine NR, McNeish IA, Meneguzzi G, Peschanski M, Roncarolo MG, Strayer DS, Tuszynski MH, Waxman DJ, Wilson JM. 2007. and prospects: gene therapy clinical trials (part 2). Gene Therapy. Vol. 14: 1555-63.
Berg C, Karas CS, Chiocca EA. 2007. Benign epithelioid peripheral nerve sheath tumor (BEPNST) of the peroneal nerve presenting with acute foot drop. Annals of Neurosurgery 7: 1-5.
Chang, Susan; Vogelbaum, Michael; Lang, Frederick, F; Haines, Stephen; Kunwar, Sandeep; Chiocca, E Antonio; Olivi, Alessandro; Quinones-Hinojosa, Alfredo; Parsa, Andrew; Warnick, Ronald; Warnick, Ronald. 2007. GNOSIS: guidelines for neuro-oncology: standards for investigational studies--reporting of surgically based therapeutic clinical trials. Journal of neuro-oncology. Vol. 82, no. 2.
Chiocca, E Antonio; Schwartzbaum, Judith A. 2007. Gliomas and venous thromboembolism: how common?. Journal of neurosurgery. Vol. 106, no. 4.
Dang, David; Baig, Mirza, N; Christoforidis, Greg; Chiocca, E Antonio; Gabriel, Joshue. 2007. C2/C3 pathologic fractures from polyostotic fibrous dysplasia of the cervical spine treated with percutaneous vertebroplasty. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. Vol. 16 Suppl 3.
Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Stemmer Rachamimov A, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA. 2007. Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Research. Vol. 67: 9398-9406.
Fulci, Giulia; Chiocca, E Antonio. 2007. The status of gene therapy for brain tumors. Expert opinion on biological therapy. Vol. 7, no. 2.
Hardcastle, Jayson; Kurozumi, Kazuhiko; Chiocca, E Antonio; Kaur, Balveen. 2007. Oncolytic viruses driven by tumor-specific promoters. Current cancer drug targets. Vol. 7, no. 2.
Ishizuka, Kelly; Oaklander, Anne Louise; Chiocca, E Antonio. 2007. A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulation. Journal of neurosurgery. Vol. 106, no. 3.
Karas CS, Chiocca EA. 2007. Neurosurgical robotics: a review of brain and spine applications. Journal of Robotic Surgery. Vol. 1: 39-43.
Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg FH, Weissleder R, Carson W, Chiocca EA, Kaur B. 2007. Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy. Journal of the National Cancer Institute 99: 1768-1781.
Suzuki, Masataka; Chiocca, E Antonio; Saeki, Yoshinaga. 2007. Early STAT1 activation after systemic delivery of HSV amplicon vectors suppresses transcription of the vector-encoded transgene. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 15, no. 11.
Chiocca EA (editorial discussion) Candolfi M, Kroeger KM, Pluhar GE, Bergeron J, Puntel M, Curtin JF, McNiel EA, Freese AB, Ohlfest JR, Moore P, Lowenstein PR, Castro MG. 2007. Adenoviral-mediated gene transfer into the canine brain in vivo. Neurosurgery. Vol. 60, no. 1. (January): 167-177; discussion 178.
Kaur B, Chiocca EA. 2007. Personalizing oncolytic virotherapy?. Molecular Therapy. Vol. 15, no. 1. (January): 6-7.
Stein AM, Nowicki MO, Demuth T, Berens ME, Lawler SE, Chiocca E, Sander L. 2007. Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro. Applied Optics 46. (August): 5110-5118.
Aghi MA, Visted T, Depinho RA, Chiocca EA. 2008. Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16. Oncogene 27: 4249-4254. (IF: 6.440)
Brem SS, Bierman PJ, Black P, Brem H, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Glass J, Grossman SA, Heimberger AB, Junck L, Linette GP, Loeffler JJ, Maor MH, Moots P, Mrugala M, Nabors LB, Newton HB, Olivi A, Por. 2008. Central nervous system cancers. J Natl Compr Canc Netw. 6: 456-504.
Chiocca EA. 2008. Being old is no fun: treatment of glioblastoma multiforme in the elderly. Journal of Neurosurgery. Vol. 108: 639-641. (IF: 1.990)
Chiocca EA. 2008. The host response to cancer virotherapy. Current Opinion in MolecularTherapeutics. Vol. 10: 38-45.
Chiocca EA, Smith KM, McKinney B, Palmer CA, Rosenfeld S, Lillehei K, Hamilton A, DeMasters BK, Judy K, Kirn D. 2008. A Phase I Trial of Ad.hIFN- Gene Therapy for Glioma. Molecular Therapy 3: 618-626. (IF: 5.862)
Currier MA, Gillespie RA, Sawtell NM, Mahller YY, Stroup G, Collins MH, Kambara H, Chiocca EA, Cripe TP. 2008. Efficacy and Safety of the Oncolytic Herpes Simplex Virus rRp450 Alone and Combined With Cyclophosphamide. Mol Ther. 16: 879-885. (IF: 5.862)
Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhuri A, Newton HB, Chiocca EA*, Lawler S. 2008. Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal. Cancer Res. 68: 9125-9130. (IF: 7.672)
Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B. 2008. MicroRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma. Cancer Res. 68: 3566-3572. (IF: 7.672)
Kurozumi K, Hardcastle J, Thakur R, Shroll J, Nowicki M, Otsuki A, Chiocca EA, Kaur B. 2008. Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. Mol Ther. 16: 1382-1391. (IF: 5.862)
Pillai P, Ray-Chaudhury A, Ammirati M, Chiocca EA. 2008. Solitary pituitary sarcoidosis with normal endocrine function. Journal of Neurosurgery 108: 591-594. (IF: 1.990)
Chiocca EA (editorial discussion) Ketter R, Rahnenführer J, Henn W, Kim YJ, Feiden W, Steudel WI, Zang KD, Urbschat S. 2008. Correspondence of tumor localization with tumor recurrence and cytogenetic progression in meningiomas. Neurosurgery. Vol. 62, no. 1. (January): 61-69; discussion 69-70. (IF: 3.007)
Chiocca EA (editorial discussion) Lefranc F, Mijatovic T, Kondo Y, Sauvage S, Roland I, Debeir O, Krstic D, Vasic V, Gailly P, Kondo S, Blanco G, Kiss R. 2008. Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells. Neurosurgery. Vol. 62, no. 1. (January): 211-221; discussion 221-2. (IF: 3.007)
Chiocca EA (editorial discussion) Ogden AT, Waziri AE, Lochhead RA, Fusco D, Lopez K, Ellis JA, Kang J, Assanah M, McKhann GM, Sisti MB, McCormick PC, Canoll P, Bruce JN. 2008. Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery. Vol. 62, no. 2. (February): 505-514; discussion 514-515. (IF: 3.007)
Chiocca EA (editorial discussion) Micallef J, Gajadhar A, Wiley J, DeSouza LV, Michael Siu KW, Guha A. 2008. Proteomics: present and future implications in neuro-oncology. Neurosurgery. Vol. 62, no. 3. (March): 539-555. (IF: 3.007)
Chiocca EA (editorial discussion) Tubbs RS, Loukas M, Shoja MM, Apaydin N, Ardalan MR, Shokouhi G, Oakes WJ. 2008. Costanzo Varolio (Constantius Varolius 1543-1575) and the Pons Varolli. Neurosurgery. Vol. 62, no. 3. (March): 734-737. (IF: 3.007)
Chiocca EA (editorial discussion)Farrell CJ, Hoh BL, Pisculli ML, Henson JW, Barker FG 2nd,Curry WT Jr. 2008. Limitations of diffusion-weighted imaging in the diagnosis of postoperative infections. Neurosurgery. Vol. 62, no. 3. (March): 577-583. (IF: 3.007)
Chiocca EA (editorial discussion) Gessi M, Legnani FG, Maderna E, Casali C, Solero CL, Pollo B, DiMeco F. 2008. Mucinous low-grade adenocarcinoma arising in an intracranial enterogenous cyst: case report. Neurosurgery. Vol. 62, no. 4. (April): E972-E973; discussion E973. (IF: 3.007)
Otsuki A, Patel A, Kasai K, Suzuki M, Kurozumi K, Chiocca EA*, Saeki Y. 2008. Histone Deacetylase Inhibitors Augment Antitumor Efficacy of Herpes-based Oncolytic Viruses. Mol Ther. 16. (July 22): 1446-1455. (IF: 5.862)
Chiocca EA (editorial discussion) McGirt MJ, Chaichana KL, Gathinji M, Attenello F, Than K, Ruiz AJ, Olivi A, Quiñones-Hinojosa A. 2008. Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas. Neurosurgery. Vol. 63, no. 2. (August): 286-291; discussion 291. (IF: 3.007)
Nowicki MO, Dmitrieva N, Stein AM, Cutter JL, Godlewski J, Saeki Y, Nita M, Berens ME, Sander LM, Newton HB, Chiocca EA*, Lawler S. 2008. Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro Oncol.10. (August 20): 690-699. (IF: 5.674)
Suzuki M, Chiocca EA*, Saeki Y. 2008. Stable Transgene Expression From HSV Amplicon Vectors in the Brain: Potential Involvement of Immunoregulatory Signals. Mol Ther. 16. (August 26): 1727-1736. (IF: 5.862)
Chiocca EA (editorial discussion) Chamberlain MC, Glantz MJ. 2008. Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. Neurosurgery. Vol. 63, no. 4. (October): 720-726; author reply 726-7. (IF: 3.007)
Chiocca EA (editorial discussion) McGirt MJ, Chaichana KL, Attenello FJ, Weingart JD, Than K, Burger PC, Olivi A, Brem H, Quinoñes-Hinojosa A. 2008. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. Vol. 63, no. 4. (October): 700-707; author reply 707-8. (IF: 3.007)
Tian J, Friedman A, Wang J, Chiocca EA. 2008. Modeling the Effects of Resection, Radiation and Chemotherapy in Glioblastoma. J. Neuro Oncol.. (October 4). (IF: 1.856)
Aghi MK, Chiocca EA. 2009. Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication. Molecular Therapy. Vol. 17: 8-9.
Chiocca EA (editorial discussion) Ogden AT, Waziri AE, Lochhead RA, Fusco D, Lopez K, Ellis JA, Kang J, Assanah M, McKhann GM, Sisti MB, McCormick PC, Canoll P, Bruce JN. 2011. Dentification of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery. Vol. 62, no. 2. (February): 505-514; discussion 514-515.
Positions
| 1995 - 1996 | Assistant, Neurosurgery; Instructor, Surgery, Massachusetts General Hospital. Boston, Massachusetts, United States. |
| 1996 - 1998 | Assistant Professor, Neurosurgery, Harvard Medical School. Boston, MA, United States. |
| 1997 - 1998 | Staff Neurosurgeon, Emerson Hospital. Concord, MA, United States. |
| 1997 - 1999 | Staff Neurosurgeon, Melrose-Wakefield Hospital. Melrose, MA, United States. |
| 1996 - 2000 | Staff Neurosurgeon, Cambridge/Somerville Hospital. Cambridge, MA, United States. |
| 1996 - 2000 | Staff Neurosurgeon, Whidden Hospital. Everett, MA, United States. |
| 1998 - 2004 | Associate Professor, Surgery (Neurosurgery), Harvard Medical School. Boston, MA, United States. |
| 1998 - 2004 | Associate Visiting Neurosurgeon, Massachusetts General Hospital. Boston, Massachusetts, United States. |
| 2004 - present | Director of Neurosurgical Services/Chairman of Department of Neurosurgery, The Ohio State University Medical Center. Columbus, OH, United States. |
Professional Activities
Community Service
Conference Participation
| 05/01/1992 | One-hour platform presentation. Adjudicator. |
| 07/01/1993 - present | One-hour platform presentation. Adjudicator. |
| 11/01/1993 - present | Twenty-minute presentation. Adjudicator. |
| 05/01/1994 - present | Twenty-minute presentation. Adjudicator. |
| 10/01/1994 - present | Resident award presentation. Adjudicator. |
| 11/01/1994 - present | Two-hour lecture. Adjudicator. |
| 04/01/1995 - present | Platform presentation. Adjudicator. |
| 05/01/1995 - present | One-hour Neuroimmunology Seminar. Adjudicator. |
| 05/01/1995 - present | Platform presentation. Adjudicator. |
| 06/01/1995 - present | One-hour lecture. Adjudicator. |
| 11/01/1995 - present | Twenty-minute presentation. Adjudicator. |
| 04/01/1996 - present | Boston University Combined Neurosciences Grand Rounds. Adjudicator. |
| 06/01/1996 - present | Invited speaker. Adjudicator. |
| 02/01/1997 - present | Invited speaker. Adjudicator. |
| 03/01/1997 - present | Invited speaker. Adjudicator. |
| 09/01/1997 - present | Invited speaker. Adjudicator. |
| 09/01/1997 - present | Invited speaker. Adjudicator. |
| 09/01/1997 - present | Invited panel member. Adjudicator. |
| 10/01/1997 - present | Invited speaker. Adjudicator. |
| 02/01/1998 - present | Invited participant. Adjudicator. |
| 03/01/1998 - present | Invited speaker. Adjudicator. |
| 03/01/1998 - present | Invited session moderator. Adjudicator. |
| 04/01/1998 - present | Invited speaker. Adjudicator. |
| 04/01/1998 - present | Invited speaker. Adjudicator. |
| 05/01/1998 - present | Invited speaker. Adjudicator. |
| 06/01/1998 - present | Invited speaker. Adjudicator. |
| 06/01/1998 - present | Invited speaker. Adjudicator. |
| 07/01/1998 - present | Invited speaker. Adjudicator. |
| 09/01/1998 - present | Invited speaker. Adjudicator. |
| 09/01/1998 - present | Invited speaker. Adjudicator. |
| 10/01/1998 - present | Invited speaker. Adjudicator. |
| 10/01/1998 - present | Invited speaker. Adjudicator. |
| 10/01/1998 - present | Invited speaker. Adjudicator. |
| 11/01/1998 - present | Invited speaker. Adjudicator. |
| 02/01/1999 - present | Invited speaker. Adjudicator. |
| 06/01/1999 - present | Invited Speaker. Adjudicator. |
| 06/01/1999 - present | Invited speaker. Adjudicator. |
| 12/01/1999 - present | Invited speaker. Adjudicator. |
| 02/01/2000 - present | Invited speaker. Adjudicator. |
| 02/01/2000 - present | Invited speaker. Adjudicator. |
| 02/01/2000 - present | Invited speaker. Adjudicator. |
| 06/01/2000 - present | Invited speaker. Adjudicator. |
| 09/01/2000 - present | Invited speaker. Adjudicator. |
| 10/01/2000 - present | Invited speaker. Adjudicator. |
| 11/01/2000 - present | Invited participant. Adjudicator. |
| 02/01/2001 - present | Invited speaker, Grand Rounds. Adjudicator. |
| 04/01/2001 - present | Invited speaker. Adjudicator. |
| 04/01/2001 - present | Invited speaker. Adjudicator. |
| 05/01/2001 - present | Invited speaker. Adjudicator. |
| 06/01/2001 - present | Invited speaker. Adjudicator. |
| 07/01/2001 - present | Visiting professor. Adjudicator. |
| 07/01/2001 - present | Invited speaker. Adjudicator. |
| 10/01/2001 - present | Invited speaker. Adjudicator. |
| 10/01/2001 - present | Invited speaker. Adjudicator. |
| 11/01/2001 - present | Invited speaker. Adjudicator. |
| 01/01/2002 - present | Visiting professor. Adjudicator. |
| 02/02/2002 - present | Invited speaker. Adjudicator. |
| 06/01/2002 - present | Invited speaker. Adjudicator. |
| 09/01/2002 - present | Invited speaker. Adjudicator. |
| 09/01/2002 - present | Invited speaker. Adjudicator. |
| 09/01/2002 - present | Invited speaker. Adjudicator. |
| 09/01/2002 - present | Invited speaker. Adjudicator. |
| 10/01/2002 - present | Invited speaker. Adjudicator. |
| 11/01/2002 - present | Invited speaker. Adjudicator. |
| 03/01/2003 - present | Invited participant. Adjudicator. |
| 03/01/2003 - present | Invited speaker. Adjudicator. |
| 03/01/2003 - present | Invited Speaker. Adjudicator. |
| 05/01/2003 - present | Invited speaker. Adjudicator. |
| 06/01/2003 - present | Invited speaker. Adjudicator. |
| 07/01/2003 - present | Invited speaker. Adjudicator. |
| 07/01/2003 - present | Invited speaker. Adjudicator. |
| 09/01/2003 - present | Organizer. Adjudicator. |
| 10/2003 | Pencher lecturer. Adjudicator. |
| 10/01/2003 - present | Invited speaker. Adjudicator. |
| 10/01/2003 - present | Organizer. Adjudicator. |
| 11/01/2003 - present | Invited speaker. Adjudicator. |
| 11/01/2003 - present | Invited speaker. Adjudicator. |
| 12/01/2003 - present | Invited speaker. Adjudicator. |
| 05/01/2004 - present | Invited speaker. Adjudicator. |
| 05/01/2004 - present | Invited speaker. Adjudicator. |
| 05/01/2004 - present | Invited speaker. Adjudicator. |
| 06/01/2004 - present | Invited speaker. Adjudicator. |
| 10/01/2004 - present | Invited speaker. Adjudicator. |
| 10/01/2004 - present | Invited speaker. Adjudicator. |
| 11/01/2004 - present | Invited speaker. Adjudicator. |
| 11/01/2004 - present | Invited speaker. Adjudicator. |
| 11/01/2004 - present | Invited speaker. Adjudicator. |
| 03/01/2005 - present | Invited speaker. Adjudicator. |
| 04/01/2005 - present | Invited speaker. Adjudicator. |
| 05/01/2005 - present | Invited speaker. Adjudicator. |
| 06/01/2005 - present | Invited speaker and organizer. Adjudicator. |
| 06/01/2005 - present | Invited speaker. Adjudicator. |
| 09/01/2005 - present | Invited speaker. Adjudicator. |
| 10/01/2005 - present | Invited speaker. Adjudicator. |
| 10/01/2005 - present | Invited speaker. Adjudicator. |
| 11/01/2005 - present | Invited speaker. Adjudicator. |
| 11/01/2005 - present | Invited speaker. Adjudicator. |
| 01/01/2006 - present | Invited speaker. Adjudicator. |
| 01/01/2006 - present | Invited speaker. Adjudicator. |
| 03/01/2006 - present | Invited speaker. Adjudicator. |
| 04/01/2006 - present | Invited speaker. Adjudicator. |
| 09/01/2006 - present | Invited speaker. Adjudicator. |
| 09/01/2006 - present | Seventh Principal Investigators Meeting. Adjudicator. |
| 09/01/2006 - present | Annual Meeting of the Ohio State Neurosurgical Society. Adjudicator. |
| 09/01/2006 - present | First Annual Neuro-oncology Symposium. Adjudicator. |
| 10/01/2006 - present | Annual Meeting, Congress of Neurological Surgeons (CNS). Adjudicator. |
| 10/01/2006 - present | Invited speaker. Adjudicator. |
| 11/01/2006 - present | Invited guest professor/faculty. Adjudicator. |
| 11/01/2006 - present | Invited guest speaker. Adjudicator. |
| 11/01/2006 - present | Invited speaker. Adjudicator. |
| 12/01/2006 - present | Panel Chair. Adjudicator. |
| 12/01/2006 - present | Invited speaker. Adjudicator. |
| 03/01/2007 - present | Invited speaker. Adjudicator. |
| 03/01/2007 - present | Course Faculty. Adjudicator. |
| 03/01/2007 - present | Invited speaker. Adjudicator. |
| 04/01/2007 - present | Panelist. Adjudicator. |
| 05/01/2007 - present | Grass Award recipient speech. Adjudicator. |
| 06/2007 | Invited speaker. Adjudicator. Rome, Italy. |
| 06/01/2007 - present | Invited speaker, Neuro-oncology. Adjudicator. |
| 06/01/2007 - present | Faculty. Adjudicator. |
| 10/22/2007 - 10/23/2007 | Invited speaker. Adjudicator. |
| 10/31/2007 - 11/02/2007 | Invited speaker. Adjudicator. |
| 11/05/2007 - present | Invited Professor. Adjudicator. |
| 12/01/2007 - 12/03/2007 | Invited Faculty. Adjudicator. |
| 01/17/2008 - present | Invited speaker. Adjudicator. |
| 02/20/2008 | Invited speaker. Adjudicator. |
| 03/13/2008 | Invited speaker. Adjudicator. |
| 03/15/2008 | Invited speaker/faculty participant. Adjudicator. |
| 04/25/2008 | Invited Speaker. Adjudicator. |
| 04/28/2008 | Discussant on Floyd et al."Differential Proteomics Signatures detected by MALDI Mass Spectrometry in GBM". Adjudicator. |
| 04/29/2008 | Invited Speaker/Breakfast Seminar. Adjudicator. |
| 04/29/2008 | Farber Lecture Award. Adjudicator. |
| 04/30/2008 | Moderator: "Stem cells in gliomas". Adjudicator. |
| 05/13/2008 | Invited speaker, Neurology Grand Rounds. Adjudicator. |
| 05/28/2008 | Invited Speaker/ Education Session: Entry and post-entry targeting of replicating vectors. Adjudicator. |
| 09/04/2008 | Speaker. Adjudicator. |
| 09/12/2008 | Invited speaker. Adjudicator. |
| 09/19/2008 | Invited speaker. Adjudicator. |
| 09/22/2008 | Invited speaker. Adjudicator. |
| 09/23/2008 | Invited speaker. Adjudicator. |
| 10/01/2008 - present | Pencher Lecturer. Adjudicator. |
| 10/16/2008 | Invited speaker. Adjudicator. |
| 10/21/2008 | Invited speaker. Adjudicator. |
| 10/30/2008 | Invited speaker. Adjudicator. |
| 11/18/2008 | Invited speaker. Adjudicator. |
| 11/23/2008 | Invited speaker. Adjudicator. |
| 11/23/2008 | Invited speaker. Adjudicator. |
Consultation
| 06/01/2007 - present | Industry. |
Education
| 06/29/2004 | Mission, Vision, Values Retreat IX. Invited Leadership Participant. Columbus, Ohio. |
| 11/22/2004 | Leadership Development Retreat X. Invited Leadership Participant. Columbus, Ohio. |
| 04/15/2005 - 04/16/2005 | Leadership, Team, Strategy: A New Triple Threat Retreat XI. Invited Leadership Participant. Columbus, Ohio. |
| 10/17/2005 | National Reputation: Value & Impact Retreat XII. Inivited Leadership Participant. Columbus, Ohio. |
| 01/11/2006 | Achieving Breakthrough Leadership/360 survey. Invited Leadership Participant. Columbus, Ohio. |
| 02/03/2006 - 02/04/2006 | Driving Change Through Improved Communication Retreat XIII. Columbus, Ohio. |
| 04/19/2006 | Realizing Staff Potential. Invited Leadership Participant. Columbus, Ohio. |
| 06/07/2006 | Realizing Staff Potential. Invited Leadership Participant. Columbus, Ohio. |
| 06/14/2006 | Realizing Staff Potential. Invited Leadership Participant. Columbus, Ohio. |
| 10/09/2006 | Building a High Performance Organization Retreat XIV. Columbus, Ohio. |
| 03/09/2007 - 03/10/2007 | Engagement + Alignment = Top Tier Retreat XV. Invited Leadership Participant. Columbus, Ohio. |
| 10/19/2007 | Teamwork, Culture, and Performance: Making the Connection Retreat XVI. Invited Leadership Participant. Columbus, Ohio. |
| 12/2008 | The Promise of One: Delivering the Power of Personalized Health Care Retreat XVII. Invited Leadership Participant. Columbus, Ohio. |
Undergrad., Grad. and Prof. Courses Taught
1996. Harvard Medical School, Gene Therapy Genetics 208.
1997. Harvard Medical School, Gene Therapy
1998. Harvard University, Gene Therapy
Winter 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Spring 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Summer 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Individual Studies 793 . 15 credit hours
Summer 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Autumn 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Winter 2012. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
