Chang-Hyuk Kwon, PhD

Current OSU Appointment

Assistant Professor, Neurological Surgery

Chapters In Books

CH Kwon. 2009. Chapter 5. Pten-deficient mouse models for high grade astrocytomas. In CNS Cancer, Models, Prognostic Factors, Targets and Therapeutic Approaches. Edited by Erwin Van Meir. New York: Humana Press.

CH Kwon, DK Burns and LF Parada. Brain Tumors. In Molecular Oncology: Causes of Cancer and Targets for Treatment. Edited by Edward Gelmann, Charles Sawyers and Frank Rauscher. Cambridge: Cambridge University Press. (In press)

Degrees

1989	B.S., Yonsei University, Biochemistry

1991	M.S., Yonsei University, Biochemistry

2003	Ph.D., University of Tennessee, Pathology

Editor Reviewed Journal Articles

LF Parada, CH Kwon, and Y Zhu. 2006. Modeling neurofibromatosis type 1 in the mouse for therapeutic intervention.  Cold Spring Harb. Symp. Quant. Biol.. Vol. 70: 173-176.

S Alcantara, J Chen, CH Kwon, and LF Parada. 2008. Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma.  Cold Spring Harb. Symp. Quant. Biol.. (November 6).

Peer Reviewed Journal Articles

KH Son and CH Kwon. 1995. Stabilization of human epidermal growth factor in aqueous formulation. Pharmaceutical Research. Vol. 12: 451-454. (IF: 3.441)

CH Kwon, X Zhu, J Zhang, LL Knoop, R Tharp, RJ Smeyne, CG Eberhart, PC Berger, and SJ Baker. 2001. Pten regulates neuronal soma size: a mouse model for Lhermitte-Duclos disease. Nature Genetics (article). Vol. 29: 404-411. (IF: 25.556)

X Zhu, CH Kwon, PW Schlosshauer, LH Ellenson, and SJ Baker. 2001. PTEN induces G1 cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells. Cancer Research. Vol. 61: 4569-4575. (IF: 7.679)

CH Kwon, X Zhu, J Zhang, and SJ Baker. 2003. mTOR is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc. Nat, Acad. Sci.. Vol. 100: 12923-12928. (IF: 9.598)

MM Fraser, X Zhu, CH Kwon, EJ Uhlmann, DH Gutmann, and SJ Baker. 2005. Pten loss causes hypertrophy and increased proliferation of astroctytes in vivo. Cancer Research. Vol. 64: 7773-7779. (IF: 7.679)

CH Kwon, BW Luikart, CM Powell, J Zhou, SA Matheny, W Zhang, Y Li, SJ Baker, and LF Parada. 2006. Pten regulates neuronal arborization and social interaction in mice. Neuron. Vol. 50: 377-388. (IF: 13.410)

CH Kwon, J Zhou, Y Li, KW Kim, LL Hensley, SJ Baker, and LF Parada. 2006. A Neuron-specific enolase cre mouse line with cre activity in specific neuronal populations. Genesis (article). Vol. 44: 130-135. (IF: 2.516)

S Ogawa, CH Kwon, J Zhou, D Koovakkattu, LF Parada, and CM Sinton. 2007. A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.  Brain Research. Vol. 1168: 112-123. (IF: 2.218)

BW Luikart, W Zhang, GA Wayman, CH Kwon, GL Westbrook, and LF Parada. 2008. Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling. J. Neuroscience. Vol. 28: 7006-7012. (IF: 7.490)

CH Kwon, D Zhao, J Chen, S Alcantara, Y Li, DK Burns, R Mason, EV-HP Lee, H Wu and LF Parada. 2008. Pten haploinsufficiency accelerates formation of high grade astrocytomas.  Cancer Research. Vol. 68: 3286-3294. (IF: 7.679)

ME Lush, Y Li, CH Kwon, J Chen, and LF Parada. 2008. Neurofibromin is required for barrel formation in the mouse somatosensory cortex.  J. Neuroscience. Vol. 28: 1580-1587. (IF: 7.49)

Y Li, BW Luikart, S Birnbaum, J Chen, CH Kwon, SG Kernie, R Bassel-Duby and LF Parada. 2008. TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment.  Neuron. Vol. 59: 399-412. (IF: 13.41)

S Alcantara*, J Chen*, CH Kwon*, EL Jackson,Y Li, DK Burns, A Alvarez-Buylla and LF Parada (* equal contribution). 2009. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.  Cancer Cell. Vol. 15. (January): 45-56. (IF: 23.858)

J Chen*, CH Kwon*, Y Li and LF Parada (* equal contribution). 2009. Inducible site-specific recombination in neural stem cells.  Genesis. (February). (IF: 2.516)

J Zhou, J Blundell, S Ogawa, CH Kwon, W Zhang, CM Sinton, CM Powell and LF Parada. 2009. Inhibition of mTor pathway suppresses anatomical, cellular and behavioral deficiencies of neuron-specific Pten knock out mice.  J. Neuroscience. (February). (IF: 7.49)

S Alcantara, B Whittemore, CH Kwon, and LF Parada. Gene expression profile of astrocytomas from Nf1 and p53 deficient mice indicate tumor development from neural stem cell lineage.  unknown. (Forthcoming)

Positions

1991 - 1998

Senior Research Scientist, Daewoong Pharmaceutical Co. Ltd, Research and Development Center. Seongam, Kyunggi-do, South Korea.

2003 - 2008

Post-doctoral fellow/Instructor, University of Texas Southwestern Medical Center, Developmental Biology. Dallas, TX, United States.

2008 - present

Assistant Professor, The Ohio State University College of Medicine, Tumor Microenvironment Program and Department of Neurological Surgery. Columbus, OH, United States.